Despite the best efforts of clinicians involved in wound care, diabetic ulcers can be hard to resolve. The slow healing of a diabetic ulcer may be due to several factors including peripheral vascular disease, neuropathy and the presence of infection. Diabetic neuropathy impacts on a wound in many ways, for example leading to overloading of the area, affecting normal wound healing processes such as angiogenesis and affecting the immune cells locally. Write an essay to consider the potential impact of diabetic neuropathy on healing in a patient with a foot ulcer. The role of the neuropeptide Substance P will be included.